Dynamic Gene Expression Profile Changes in Synovial Fluid Following Meniscal Injury; Osteoarthritis (OA) Markers Found
نویسندگان
چکیده
Danica D. Vance1*, Liyong Wang2, Evadnie Rampersaud2, Bryson P. Lesniak1, Jeffery M. Vance2, Margaret A. Pericak-Vance2 and Lee D. Kaplan1 1UHealth Sports Performance and Wellness Institute, University of Miami, Miller School of Medicine, Miami, Florida 2John P. Hussman Institute for Human Genomics, University of Miami, Miami Miller School of Medicine, Miami, Florid Journal of Exercise, Sports & Orthopedics Open Access Research Article
منابع مشابه
Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury
In the present study, the levels of synovial fluid biomarkers of patients with knee osteoarthritis (OA) and those with meniscus injury (MI) were compared to associate the levels of synovial fluid biomarkers with the degree of OA and MI. Synovial fluid samples were obtained from 51 cases with OA and 40 patients with MI. Severity of OA and MI were evaluated using the Kellgren-Lawrence (K-L) class...
متن کاملSynovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to toll-like receptor 4 and toll-like receptor 2 ligands via soluble CD14.
OBJECTIVE Synovial inflammation, a feature of both osteoarthritis (OA) and meniscal injury, is hypothesized to be triggered in part via stimulation of Toll-like receptors (TLRs). We undertook this study to test whether a TLR-2- or TLR-4-stimulating factor in synovial fluid (SF) from patients with early knee OA with meniscal injury could lead to inflammatory activation of synoviocytes. METHODS...
متن کاملNeuroimmune expression in hip osteoarthritis: a systematic review
BACKGROUND Neuroimmune axis is central in the physiopathology of hip osteoarthritis (OA), but its specific pathways are still unclear. This systematic review aims to assess the nervous and immune system profile of patients with hip osteoarthritis (OA) when compared to healthy controls. METHODS A systematic review followed PRISMA guidelines was conducted. A two-step selection process was compl...
متن کاملActivation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage.
OBJECTIVE The objectives of this study were to (1) determine the correlation between osteoarthritis (OA) and Indian hedgehog (Ihh) expression, and (2) establish the effects of Ihh on expression of markers of chondrocyte hypertrophy and matrix metalloprotease (MMP)-13 in human OA cartilage. DESIGN OA cartilage and synovial fluid samples were obtained during total knee arthroplasty. Normal cart...
متن کاملCalcium deposition in osteoarthritic meniscus and meniscal cell culture
INTRODUCTION Calcium crystals exist in the knee joint fluid of up to 65% of osteoarthritis (OA) patients and the presence of these calcium crystals correlates with the radiographic evidence of hyaline cartilaginous degeneration. This study sought to examine calcium deposition in OA meniscus and to investigate OA meniscal cell-mediated calcium deposition. The hypothesis was that OA meniscal cell...
متن کامل